Dermatology
Fitzpatrick’s Dermatology 2019
The acclaimed masterwork of dermatology --- reinvented by an all new editorial team
For nearly half a century Fitzpatrick’s has been recognized worldwide as the field of dermatology’s cornerstone text. This trusted classic covers all of the essentials, from the basic science of the skin to the day-to-day clinical issues of managing common skin disorders. Backed by the expertise of more than 500 world-renowned contributors, it is the reference of choice for clinicians, students, and educators. Fitzpatrick’s skillful blending of science and clinical medicine is matched only by its scope, level of detail, and quality of presentation.
The Ninth Edition continues this tradition of excellence with sweeping changes designed to make it even more relevant to today’s practice and education.
The ALL-NEW Fitzpatrick’s:
New editors diverse in expertise and international in location of practice have endeavored to build on the achievements of previous editions, while providing fresh insight into the content and new thinking regarding optimal structure of the book
Reorganized and updated content – important general basic science concepts are extensively covered in dedicated chapters appearing at the beginning of the book, allowing subsequent clinical chapters to focus on relevant disease-specific pathophysiology, in addition to clinical features, diagnosis, clinical course, and management
Unmatched visual presentation includes more than 3,000 illustrations, including more than 2,700 full-color photographs; all tables and At-a-Glance boxes are either new or completely revised
An improved index to speed you to the information you require about a concept, condition, or therapy
Table of contents :
Cover......Page 1
Title Page......Page 5
Copyright Page......Page 6
Contents......Page 7
Contributors......Page 15
Preface......Page 31
Acknowledgments......Page 33
1 Fundamentals of Clinical Dermatology: Morphology and Special Clinical Considerations......Page 35
2 Pathology of Skin Lesions......Page 52
3 Epidemiology and Public Health in Dermatology......Page 74
4 Developmental Biology of the Skin......Page 83
5 Growth and Differentiation of the Epidermis......Page 96
6 Skin Glands: Sebaceous, Eccrine, and Apocrine Glands......Page 104
7 Biology of Hair Follicles......Page 123
8 Nail......Page 140
9 Cutaneous Vasculature......Page 150
10 The Immunological Structure of the Skin......Page 164
11 Cellular Components of the Cutaneous Immune System......Page 177
12 Soluble Mediators of the Cutaneous Immune System......Page 193
13 Basic Principles of Immunologic Diseases in Skin (Pathophysiology of Immunologic/Inflammatory Skin Diseases)......Page 226
14 Skin Barrier......Page 240
15 Epidermal and Dermal Adhesion......Page 266
16 Microbiome of the Skin......Page 287
17 Cutaneous Photobiology......Page 299
18 Genetics in Relation to the Skin......Page 323
19 Carcinogenesis and Skin......Page 344
20 Pigmentation and Melanocyte Biology......Page 362
21 Neurobiology of the Skin......Page 385
22 Atopic Dermatitis......Page 397
23 Nummular Eczema, Lichen Simplex Chronicus, and Prurigo Nodularis......Page 419
24 Allergic Contact Dermatitis......Page 429
25 Irritant Dermatitis......Page 448
26 Seborrheic Dermatitis......Page 462
27 Occupational Skin Diseases......Page 472
28 Psoriasis......Page 491
29 Pityriasis Rubra Pilaris......Page 532
30 Parapsoriasis and Pityriasis Lichenoides......Page 539
31 Pityriasis Rosea......Page 552
32 Lichen Planus......Page 561
33 Lichen Nitidus and Lichen Striatus......Page 588
34 Granuloma Annulare......Page 598
35 Sarcoidosis......Page 606
36 Sweet Syndrome......Page 621
37 Pyoderma Gangrenosum......Page 639
38 Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease)......Page 651
39 Autoinflammatory Disorders......Page 655
40 Eosinophilic Diseases......Page 683
41 Urticaria and Angioedema......Page 718
42 Mastocytosis......Page 744
43 Erythema Multiforme......Page 757
44 Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis)......Page 767
45 Cutaneous Reactions to Drugs......Page 783
46 Erythema Annulare Centrifugum and Other Figurate Erythemas......Page 799
47 The Ichthyoses......Page 809
48 Inherited Palmoplantar Keratodermas......Page 850
49 Keratosis Pilaris and Other Follicular Keratotic Disorders......Page 901
50 Acantholytic Disorders of the Skin......Page 911
51 Porokeratosis......Page 935
52 Pemphigus......Page 943
53 Paraneoplastic Pemphigus......Page 968
54 Bullous Pemphigoid......Page 978
55 Mucous Membrane Pemphigoid......Page 994
56 Epidermolysis Bullosa Acquisita......Page 1005
57 Intercellular Immunoglobulin (Ig) A Dermatosis (IgA Pemphigus)......Page 1015
58 Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood......Page 1026
59 Dermatitis Herpetiformis......Page 1036
60 Inherited Epidermolysis Bullosa......Page 1045
61 Lupus Erythematosus......Page 1071
62 Dermatomyositis......Page 1095
63 Systemic Sclerosis......Page 1120
64 Morphea and Lichen Sclerosus......Page 1140
65 Psoriatic Arthritis and Reactive Arthritis......Page 1161
66 Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, Adult-Onset Still Disease, and Rheumatic Fever......Page 1180
67 Scleredema and Scleromyxedema......Page 1197
68 Sjögren Syndrome......Page 1204
69 Relapsing Polychondritis......Page 1220
70 Anetoderma and Other Atrophic Disorders of the Skin......Page 1227
71 Acquired Perforating Disorders......Page 1237
72 Genetic Disorders Affecting Dermal Connective Tissue......Page 1246
73 Panniculitis......Page 1285
74 Lipodystrophy......Page 1329
75 Albinism and Other Genetic Disorders of Pigmentation......Page 1343
76 Vitiligo......Page 1364
77 Hypermelanoses......Page 1385
78 Acne Vulgaris......Page 1425
79 Rosacea......Page 1453
80 Acne Variants and Acneiform Eruptions......Page 1482
81 Hyperhidrosis and Anhidrosis......Page 1493
82 Bromhidrosis and Chromhidrosis......Page 1503
83 Fox-Fordyce Disease......Page 1509
84 Hidradenitis Suppurativa......Page 1514
85 Androgenetic Alopecia......Page 1529
86 Telogen Effluvium......Page 1541
87 Alopecia Areata......Page 1551
88 Cicatricial Alopecias......Page 1558
89 Hair Shaft Disorders......Page 1571
90 Hirsutism and Hypertrichosis......Page 1589
91 Nail Disorders......Page 1602
92 Polymorphic Light Eruption......Page 1645
93 Actinic Prurigo......Page 1662
94 Hydroa Vacciniforme......Page 1668
95 Actinic Dermatitis......Page 1673
96 Solar Urticaria......Page 1684
97 Phototoxicity and Photoallergy......Page 1691
98 Cold Injuries......Page 1700
99 Burns......Page 1713
100 Delusional, Obsessive-Compulsive, and Factitious Skin Diseases......Page 1727
101 Drug Abuse......Page 1739
102 Physical Abuse......Page 1751
103 Neonatal Dermatology......Page 1761
104 Pediatric and Adolescent Dermatology......Page 1784
105 Skin Changes and Diseases in Pregnancy......Page 1799
106 Skin Aging......Page 1813
107 Caring for LGBT Persons in Dermatology......Page 1826
108 Benign Epithelial Tumors, Hamartomas, and Hyperplasias......Page 1833
109 Appendage Tumors of the Skin......Page 1854
110 Epithelial Precancerous Lesions......Page 1891
111 Basal Cell Carcinoma and Basal Cell Nevus Syndrome......Page 1918
112 Squamous Cell Carcinoma and Keratoacanthoma......Page 1935
113 Merkel Cell Carcinoma......Page 1954
114 Paget’s Disease......Page 1968
115 Melanocytic Nevi......Page 1978
116 Melanoma......Page 2016
117 Histiocytosis......Page 2052
118 Vascular Tumors......Page 2076
119 Cutaneous Lymphoma......Page 2106
120 Cutaneous Pseudolymphoma......Page 2142
121 Neoplasias and Hyperplasias of Muscular and Neural Origin......Page 2164
122 Lipogenic Neoplasms......Page 2206
123 Cutaneous Changes in Nutritional Disease......Page 2233
124 The Porphyrias......Page 2268
125 Amyloidosis......Page 2292
126 Xanthomas and Lipoprotein Disorders......Page 2307
127 Fabry Disease......Page 2326
128 Calcium and Other Mineral Deposition Disorders......Page 2341
129 Graft-Versus-Host Disease......Page 2354
130 Hereditary Disorders of Genome Instability and DNA Repair......Page 2376
131 Ectodermal Dysplasias......Page 2406
132 Genetic Immunodeficiency Diseases......Page 2428
133 Skin Manifestations of Internal Organ Disorders......Page 2459
134 Cutaneous Paraneoplastic Syndromes......Page 2475
135 The Neurofibromatoses......Page 2499
136 Tuberous Sclerosis Complex......Page 2514
137 Diabetes and Other Endocrine Diseases......Page 2527
138 Cutaneous Necrotizing Venulitis......Page 2561
139 Systemic Necrotizing Arteritis......Page 2573
140 Erythema Elevatum Diutinum......Page 2596
141 Adamantiades–Behçet Disease......Page 2601
142 Kawasaki Disease......Page 2614
143 Pigmented Purpuric Dermatoses......Page 2624
144 Cryoglobulinemia and Cryofibrinogenemia......Page 2633
145 Raynaud Phenomenon......Page 2647
146 Malignant Atrophic Papulosis (Degos Disease)......Page 2664
147 Vascular Malformations......Page 2670
148 Cutaneous Changes in Arterial, Venous, and Lymphatic Dysfunction......Page 2703
149 Wound Healing......Page 2734
150 Superficial Cutaneous Infections and Pyodermas......Page 2753
151 Cellulitis and Erysipelas......Page 2780
152 Gram-Positive Infections Associated with Toxin Production......Page 2791
153 Necrotizing Fasciitis, Necrotizing Cellulitis, and Myonecrosis......Page 2804
154 Gram-Negative Coccal and Bacillary Infections......Page 2816
155 The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation......Page 2849
156 Miscellaneous Bacterial Infections with Cutaneous Manifestations......Page 2861
157 Tuberculosis and Infections with Atypical Mycobacteria......Page 2892
158 Actinomycosis, Nocardiosis, and Actinomycetoma......Page 2910
159 Leprosy......Page 2926
160 Superficial Fungal Infection......Page 2959
161 Yeast Infections......Page 2986
162 Deep Fungal Infections......Page 2999
163 Exanthematous Viral Diseases......Page 3023
164 Herpes Simplex......Page 3055
165 Varicella and Herpes Zoster......Page 3069
166 Poxvirus Infections......Page 3099
167 Human Papillomavirus Infections......Page 3129
168 Cutaneous Manifestations of HIV and Human T-Lymphotropic Virus......Page 3141
169 Mosquito-Borne Viral Diseases......Page 3169
170 Syphilis......Page 3179
171 Endemic (Nonvenereal) Treponematoses......Page 3207
172 Chancroid......Page 3220
173 Lymphogranuloma Venereum......Page 3227
174 Granuloma Inguinale......Page 3236
175 Gonorrhea, Mycoplasma, and Vaginosis......Page 3241
176 Leishmaniasis and Other Protozoan Infections......Page 3257
177 Helminthic Infections......Page 3285
178 Scabies, Other Mites, and Pediculosis......Page 3308
179 Lyme Borreliosis......Page 3321
180 The Rickettsioses, Ehrlichioses, and Anaplasmoses......Page 3340
181 Arthropod Bites and Stings......Page 3358
182 Bites and Stings of Terrestrial and Aquatic Life......Page 3372
183 Principles of Topical Therapy......Page 3397
184 Glucocorticoids......Page 3416
185 Retinoids......Page 3429
186 Systemic and Topical Antibiotics......Page 3441
187 Dapsone......Page 3457
188 Antifungals......Page 3470
189 Antihistamines......Page 3485
190 Cytotoxic and Antimetabolic Agents......Page 3497
191 Antiviral Drugs......Page 3527
192 Immunosuppressive and Immunomodulatory Drugs......Page 3551
193 Immunobiologics: Targeted Therapy Against Cytokines, Cytokine Receptors, and Growth Factors in Dermatology......Page 3565
194 Molecular Targeted Therapies......Page 3592
195 Antiangiogenic Agents......Page 3624
196 Other Topical Medications......Page 3644
197 Photoprotection......Page 3657
198 Phototherapy......Page 3669
199 Photochemotherapy and Photodynamic Therapy......Page 3698
200 Radiotherapy......Page 3721
201 Cutaneous Surgical Anatomy......Page 3731
202 Perioperative Considerations in Dermatologic Surgery......Page 3740
203 Excisional Surgery and Repair, Flaps, and Grafts......Page 3760
204 Mohs Micrographic Surgery......Page 3795
205 Nail Surgery......Page 3808
206 Cryosurgery and Electrosurgery......Page 3825
207 Cosmeceuticals and Skin Care in Dermatology......Page 3837
208 Fundamentals of Laser and Light-Based Treatments......Page 3854
209 Laser Skin Resurfacing: Cosmetic and Medical Applications......Page 3868
210 Nonablative Laser and Light-Based Therapy: Cosmetic and Medical Indications......Page 3880
211 Noninvasive Body Contouring......Page 3891
212 Treatment of Varicose Veins and Telangiectatic Lower-Extremity Vessels......Page 3905
213 Chemical Peels and Dermabrasion......Page 3929
214 Liposuction Using Tumescent Local Anesthesia......Page 3940
215 Soft-Tissue Augmentation......Page 3945
216 Botulinum Toxin......Page 3955
217 Hair Transplantation......Page 3965
