Rheumatology, 2-Volume Set, 6e


Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritativecoverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner.
"My lasting impression of this book was the very same as the first time I opened these two lavish volumes and that was - wow! This two volume set is a spectacular and seemingly comprehensive review of rheumatology." Reviewed by: Dr Harry Brown Date: Jan 2015

Table of contents : Content:
Front Matter, Pages i-iii
Copyright, Page iv
Dedication, Page v
Contributors, Pages vii-xxii
Preface, Page xxiii
Acknowledgments, Page xxv
1 - Epidemiologic concepts and classification of rheumatic and musculoskeletal conditions, Pages 1-8
2 - Principles of clinical outcome assessment, Pages 9-19
3 - Principles of health economics and application to rheumatic disorders, Pages 20-26
4 - The synovium, Pages 27-32
5 - Articular cartilage, Pages 33-41
6 - Bone structure and function, Pages 42-55
7 - Tendons and ligaments, Pages 56-60
8 - Connective tissue responses to mechanical stress, Pages 61-64
9 - Biomechanics of peripheral joints, Pages 65-71
10 - Biomechanics of the spine, Pages 72-79
11 - Principles of genetic epidemiology, Pages 80-85
12 - Principles and techniques in molecular biology, Pages 86-98
13 - Cytokines, Pages 99-112
14 - Signal transduction in immune cells, Pages 113-118
15 - Principles of adaptive immunity, Pages 119-126
16 - Principles of innate immunity, Pages 127-133
17 - Systems biology, Pages 134-138
18 - Epigenetics in rheumatology, Pages 139-144
19 - The microbiome in rheumatic diseases, Pages 145-151
20 - Tissue destruction and repair, Pages 152-159
21 - Principles of tissue engineering and cell- and gene-based therapy, Pages 160-164
22 - Osteoimmunology, Pages 165-168
23 - Inflammation and its mediators, Pages 169-182
24 - Scientific basis of pain, Pages 183-187
25 - Effects of the neuroendocrine system on development and function of the immune system, Pages 188-196
26 - Interpreting the medical literature for the rheumatologist: Study design and levels of evidence, Pages 197-203
27 - Ethics in clinical trials, Pages 204-208
28 - History and physical examination, Pages 209-224
29 - Pattern recognition in arthritis, Pages 225-230
30 - Role of laboratory tests in rheumatic disorders, Pages 231-236
31 - Synovial fluid analysis, Pages 237-241
32 - Minimally invasive procedures, Pages 242-249
33 - Skin in rheumatic disease, Pages 250-259
34 - The eye in rheumatic disease, Pages 260-266
35 - The heart in rheumatic disease, Pages 267-273
36 - The lung in rheumatic disease, Pages 274-278
37 - Gastrointestinal tract and rheumatic disease, Pages 279-285
38 - The kidney and rheumatic disease, Pages 286-297
39 - The nervous system in rheumatic disease, Pages 298-305
40 - Conventional radiography and computed tomography, Pages 307-321
41 - Functional magnetic resonance imaging, Pages 322-330
42 - Musculoskeletal ultrasound, Pages 331-341
43 - Bone scintigraphy and positron emission tomography, Pages 342-348
44 - Dual x-ray absorptiometry and measurement of bone, Pages 349-357
45 - Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials, Pages 358-368
46 - Arthritis patient education, health promotion, and team approaches to management, Pages 369-374
47 - Principles of rehabilitation: Physical and occupational therapy, Pages 375-381
48A - Complementary and alternative medicine, Pages 382-389
48B - Placebos, caring, and healing in rheumatology, Pages 390-394
49 - Drug development, Pages 395-400
50 - Nonpharmacologic pain management, Pages 401-405
51 - Pharmacogenomics in rheumatology, Pages 406-409
52 - Principles of opioid treatment of chronic musculoskeletal pain, Pages 410-414.e1
53 - Nonsteroidal antiinflammatory drugs, Pages 415-422
54 - Systemic glucocorticoids in rheumatology, Pages 423-433
55 - Nonimmunosuppressive disease-modifying antirheumatic drugs, Pages 434-442
56 - Methotrexate*, Pages 443-450
57 - Leflunomide, Pages 451-458
58 - Immunosuppressives: Cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil, Pages 459-467
59 - T-cell costimulation and other directed therapies, Pages 468-471
60 - B-cell depletion, Pages 472-478
61 - Cytokine neutralizers: Interleukin-1 inhibitors, Pages 479-484
62 - Interleukin-6 inhibition, Pages 485-491
63 - Tumor necrosis factor–blocking therapies, Pages 492-510
64 - Kinase inhibition: A new therapeutic principle in rheumatology, Pages 511-517
65 - Emerging therapeutic targets: GM-CSF, IL-17, and IL-23, Pages 518-521
66 - Biosimilars in rheumatology, Pages 522-529
67 - Infections and biologic therapy for rheumatoid arthritis: An update on risk and prevention, Pages 530-535
68 - Drugs and pregnancy, Pages 536-541
69 - Aspiration and injection of joints and periarticular tissue and intralesional therapy, Pages 542-553
70 - Perioperative care of patients with rheumatic disease, Pages 554-565
71 - Neck pain, Pages 567-577
72 - Lumbar spine disorders, Pages 578-594
73 - The shoulder, Pages 595-610
74 - The elbow, Pages 611-618
75 - The wrist and hand, Pages 619-625
76 - The hip, Pages 626-632
77 - The knee, Pages 633-646
78 - The ankle and foot, Pages 647-655
79 - The temporomandibular joint, Pages 656-658
80 - Fibromyalgia and related syndromes, Pages 659-670
81 - Entrapment neuropathies and compartment syndromes, Pages 671-682
82 - Complex regional pain syndrome, Pages 683-689
83 - Classification and epidemiology of rheumatoid arthritis, Pages 691-697
84 - Preclinical features of rheumatoid arthritis, Pages 698-703
85 - Clinical features of rheumatoid arthritis, Pages 704-711
86 - Extraarticular features of rheumatoid arthritis and systemic involvement, Pages 712-719
87 - Adult-onset Still disease, Pages 720-726
88 - Imaging of rheumatoid arthritis, Pages 727-734
89 - The contribution of genetic factors to rheumatoid arthritis, Pages 735-742
90 - Animal models of arthritis, Pages 743-749
91 - Autoantibodies in rheumatoid arthritis, Pages 750-757
92 - Cellular immunity in rheumatoid arthritis, Pages 758-763
93 - Angiogenesis and vasculogenesis in rheumatoid arthritis, Pages 764-767
94 - The rheumatoid joint: Synovitis and tissue destruction, Pages 768-784
95 - Evaluation and management of early inflammatory polyarthritis, Pages 785-789
96 - Evaluation and outcomes of patients with rheumatoid arthritis, Pages 790-801
97 - Management of rheumatoid arthritis: synovitis, Pages 802-808
98 - Multidisciplinary approach to rheumatoid arthritis, Pages 809-814
99A - Evaluation of musculoskeletal complaints in children: Clinical evaluation, Pages 815-819
99B - Evaluation of musculoskeletal complaints in children: Nonautoimmune musculoskeletal disorders, Pages 820-825
100 - Classification and epidemiology of juvenile idiopathic arthritis, Pages 826-832
101 - Clinical features of juvenile idiopathic arthritis, Pages 833-844
102 - Etiology and pathogenesis of juvenile idiopathic arthritis, Pages 845-850
103 - Management of juvenile idiopathic arthritis, Pages 851-861
104 - Juvenile-onset spondyloarthritis, Pages 862-867
105 - Connective tissue diseases in children, Pages 868-875
106 - Rehabilitation and psychosocial issues in juvenile idiopathic arthritis, Pages 876-883
107 - Infectious arthritis I: Bacterial arthritis, Pages 885-893
108 - Infectious arthritis II: Mycobacterial, brucellar, fungal, and parasitic arthritis, Pages 894-904
109 - Lyme disease, Pages 905-911
110 - Rheumatologic aspects of viral infections, Pages 912-917
111 - Acute rheumatic fever, Pages 918-927
112 - Reactive arthritis, Pages 928-940
113 - Classification and epidemiology of spondyloarthritis, Pages 941-945
114 - Clinical features of axial spondyloarthritis, Pages 946-950
115 - Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis, Pages 951-955
116 - Genetics of axial spondyloarthritis, Pages 956-959
117 - Imaging in spondyloarthritis, Pages 960-969
118 - Management of ankylosing spondylitis/axial spondyloarthritis, Pages 970-985
119 - Classification and epidemiology of psoriatic arthritis, Pages 986-988
120 - Clinical features of psoriatic arthritis, Pages 989-997
121 - Etiology and pathogenesis of psoriatic arthritis, Pages 998-1007
122 - Management of psoriatic arthritis, Pages 1008-1013
123 - Enthesopathies, Pages 1014-1020
124 - Epidemiology and classification of systemic lupus erythematosus, Pages 1021-1025
125 - Preclinical features of lupus, Pages 1026-1031
126 - Clinical features of systemic lupus erythematosus, Pages 1032-1044
127 - Genetics of lupus, Pages 1045-1051
128 - Immunopathology of systemic lupus erythematosus, Pages 1052-1067
129 - Animal models of lupus, Pages 1068-1073
130 - Autoantibodies in systemic lupus erythematosus, Pages 1074-1081
131 - Pathogenesis of lupus, Pages 1082-1087
132 - Drug-induced lupus, Pages 1088-1092
133 - Assessing disease activity and outcome in systemic lupus erythematosus, Pages 1093-1098
134 - Management of nonrenal and non–central nervous system lupus, Pages 1099-1106
135 - Treatment of neuropsychiatric lupus, Pages 1107-1111
136 - Systemic lupus erythematosus: Treatment—renal involvement, Pages 1112-1126
137 - Systemic lupus erythematosus in the pregnant patient and neonatal lupus, Pages 1127-1130
138 - Sjögren syndrome, Pages 1131-1143
139 - Antiphospholipid syndrome: Overview of pathogenesis, diagnosis, and management, Pages 1144-1152
140 - Classification and epidemiology of scleroderma, Pages 1153-1158
141 - Assessing disease activity and outcome in systemic sclerosis (scleroderma), Pages 1159-1164
142 - Clinical features of systemic sclerosis, Pages 1165-1176
143 - Etiology and pathogenesis of systemic sclerosis, Pages 1177-1189
144 - Management of systemic sclerosis, Pages 1190-1199
145 - Pulmonary management of systemic sclerosis, Pages 1200-1212
146 - Raynaud phenomenon, Pages 1213-1218
147 - Localized scleroderma and scleroderma-like syndromes, Pages 1219-1223
148 - Clinical features, classification, and epidemiology of inflammatory muscle disease, Pages 1224-1236
149 - Inflammatory muscle disease: etiology and pathogenesis, Pages 1237-1247
150 - Management of inflammatory muscle disease, Pages 1248-1254
151 - Metabolic, drug-induced, and other noninflammatory myopathies, Pages 1255-1263
152 - Overlap syndromes, Pages 1264-1269
153 - Classification and epidemiology of vasculitis, Pages 1271-1279.e1
154 - Biology and immunopathogenesis of vasculitis, Pages 1280-1289
155 - Polyarteritis nodosa and Cogan syndrome, Pages 1290-1299
156 - Polymyalgia rheumatica and giant cell arteritis, Pages 1300-1309
157 - Antineutrophil cytoplasmic antibody–associated vasculitis, Pages 1310-1321
158 - Takayasu arteritis, Pages 1322-1327
159 - Behçet syndrome, Pages 1328-1333
160 - Kawasaki disease, Pages 1334-1337
161 - Henoch-Schönlein purpura/immunoglobulin-A vasculitis, Pages 1338-1343
162 - Cutaneous vasculitis and panniculitis, Pages 1344-1353
163 - Cryoglobulinemia, Pages 1354-1359
164 - Primary angiitis of the central nervous system, Pages 1360-1367
165 - Monogenic autoinflammatory diseases, Pages 1369-1391
166 - Sarcoidosis, Pages 1392-1400
167 - Relapsing polychondritis, Pages 1401-1405
168 - Amyloidosis, Pages 1406-1414
169 - Digital clubbing and hypertrophic osteoarthropathy, Pages 1415-1419
170 - Miscellaneous arthropathies, Pages 1420-1431
171 - Osteoarthritis: Epidemiology and classification, Pages 1433-1440
172 - Local and systemic risk factors for incidence and progression of osteoarthritis, Pages 1441-1446
173 - Clinical features of osteoarthritis, Pages 1447-1453
174 - Animal models of osteoarthritis, Pages 1454-1461
175 - Pathogenesis and pathology of osteoarthritis, Pages 1462-1476
176 - Genetics of osteoarthritis, Pages 1477-1482
177 - Imaging of osteoarthritis, Pages 1483-1491
178 - Assessment of the patient with osteoarthritis and measurement of outcomes, Pages 1492-1497
179 - Preclinical osteoarthritis, Pages 1498-1502
180 - Assessment of imaging outcomes in osteoarthritis, Pages 1503-1507
181 - Management of osteoarthritis, Pages 1508-1514
182 - Diffuse idiopathic skeletal hyperostosis, Pages 1515-1520
183 - Neuropathic arthropathy, Pages 1521-1527
184 - Osteonecrosis, Pages 1528-1535
185 - Rare osteoarthritis: Ochronosis and Kashin-Beck disease, Pages 1536-1547
186 - Epidemiology of gout, Pages 1549-1554
187 - Etiology and pathogenesis of gout, Pages 1555-1568
188 - Clinical gout, Pages 1569-1574
189 - Management of gout and hyperuricemia, Pages 1575-1582
190 - Calcium pyrophosphate crystal–associated arthropathy, Pages 1583-1595
191 - Basic calcium phosphate crystal deposition disease, Pages 1596-1603
192 - Other crystal-related arthropathies, Pages 1604-1608
193 - Rheumatoid manifestations of endocrine and lipid disease, Pages 1609-1614
194 - Hemophilia and von Willebrand disease, Pages 1615-1622
195 - Joint and bone lesions in hemoglobinopathies, Pages 1623-1627
196 - Hemochromatosis, Pages 1628-1632
197 - Epidemiology and classification of osteoporosis, Pages 1633-1640
198 - Clinical features of osteoporosis, Pages 1641-1649
199 - Pathophysiology of osteoporosis, Pages 1650-1655
200 - Biochemical markers in bone disease, Pages 1656-1662
201 - Management of osteoporosis, Pages 1663-1673
202 - Glucocorticoid-induced osteoporosis, Pages 1674-1679
203 - Osteomalacia and rickets, Pages 1680-1687
204 - Primary hyperparathyroidism: Rheumatologic manifestations and bone disease, Pages 1688-1691
205 - Renal osteodystrophy, Pages 1692-1697
206 - Paget disease of bone, Pages 1698-1704
207 - Gaucher disease, Pages 1705-1710
208 - Mucopolysaccharidoses, Pages 1711-1714
209 - Heritable connective tissue disorders, Pages 1715-1723
210 - Hypermobility syndrome, Pages 1724-1727
211 - Skeletal dysplasias, Pages 1728-1733
212 - Bone tumors, Pages 1734-1743
Index, Pages i1-i82