Textbook of Pleural Diseases (Hodder Arnold Publication) - 2nd edition


This is an internationally respected and authoritative work, providing in-depth coverage of all aspects of pleural disease. Building on the strengths of the well-received first edition, the book includes a thorough basic science section, aiding understanding of the physiological and pathophysiological mechanisms that underlie diseases of the pleura. This is followed by a series of chapters discussing clinical aspects of the common (and less common) pleural diseases. Chapters in the clinical section--with authors from 10 countries--are written in an accessible and uniform style, making extensive use of illustrative material and covering definition, incidence and epidemiology, etiology and pathogenesis, clinical presentation, investigations, treatments, possible complications and directions for future developmetn. Chapters present 'state-of-the-art' scientific knowledge, but are written with sufficient clarity as to be understood by clinicians with only a limited science background. All published managment guidelines are included, each chapter concludes with a summary of the 'key points,' highlighting practical messages regarding patient management for the reader, and a comprehensive reference list is provided. In a final chapter, the editors endeavour to rpedict how the area of pleural disease may develop in forthcoming decades.The book is an indispensable reference for pulmonologists with an interest in pleural disease, and is a useful reference for other pulmonary physicians and trainees in respiratory medicine.


Table of contents : Book title......Page 4
Contents......Page 6
Contributors......Page 10
Preface......Page 14
Acknowledgements......Page 16
E......Page 18
N......Page 19
T......Page 20
X......Page 21
Reference annotations......Page 22
1 Pleural disease: historic perspective......Page 24
PART ONE: BASIC SCIENCE......Page 34
2 Anatomy of the pleura......Page 36
3 Mesothelial cells......Page 50
4 Normal physiological fluid and cellular contents......Page 62
5 Physiology: fluid and solute exchange in normal physiological states......Page 66
6 Physiology: changes with pleural effusion and pneumothorax......Page 72
7 Pleural inflammation and infection......Page 82
8 Immunology......Page 94
9 Pleural fibrosis......Page 124
10 Pleural reaction to mineral dusts......Page 136
11 Genetic alterations in mesothelioma pathogenesis......Page 148
12 Proteomics in pleural disease......Page 158
13 Pleural pharmacokinetics......Page 174
14 Experimental models: pleural disease other than mesothelioma......Page 192
15 Experimental models: mesothelioma......Page 210
PART TWO: CLINICAL SCIENCE......Page 222
16 Approach to patients with pleural diseases......Page 224
17 Pleural fluid analysis......Page 232
18 Pleural manometry......Page 250
19 Radiology: diagnostic......Page 256
20 Radiology: interventional......Page 282
21 Radiology: pleural ultrasound......Page 294
22 Pathology: histology......Page 308
23 Pathology: cytology......Page 316
24 Effusions from cardiac diseases......Page 338
25 Effusions from malignancy......Page 346
26 Effusions from infections: parapneumonic effusions and empyema......Page 364
27 Effusions from infections: tuberculosis......Page 390
28 Effusions from infections: atypical infections......Page 402
29 Effusions from lymphatic disruptions......Page 412
30 Effusions from vascular causes......Page 420
31 Effusions in immunocompromised hosts......Page 432
32 Effusions from connective tissue diseases......Page 444
33 Effusions caused by drugs......Page 454
34 Effusions after surgery......Page 468
35 Hepatic hydrothorax......Page 478
36 Effusions caused by gastrointestinal disease......Page 488
37 Effusions of obstetric or gynecological origin......Page 496
38 Benign fibrous tumor of the pleura......Page 506
39 Undiagnosed pleural effusions......Page 514
40 Asbestos-related pleural diseases......Page 522
41 Malignant mesothelioma......Page 530
42 Spontaneous pneumothorax......Page 538
43 Non-spontaneous pneumothorax......Page 556
44 Pediatric pleural diseases......Page 568
45 Drainage techniques......Page 574
46 Pleurodesis......Page 592
47 Medical thoracoscopy......Page 606
48 Surgery for pleural diseases......Page 622
49 Gene therapy in pleural diseases......Page 636
50 Future directions......Page 644