Tuesday, January 17, 2017

Umbilical Cord Blood Banking and Transplantation

This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. 

UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Table of contents : 
Front Matter....Pages i-xiii
Applications of Umbilical Cord Blood-Derived Stem Cells in Vascular Medicine....Pages 1-16
Regenerative Potential of Cord Blood....Pages 17-38
Quality Control in Cord Blood Banking....Pages 39-47
Maternal HLA Typing and Cord Blood Unit Choice....Pages 49-58
Optimizing Donor and Cord Blood Unit Selection for Banking and Transplantation....Pages 59-71
Cord Blood Transplantation for Pediatric Hematologic Malignancies: Indications, Mechanisms, and Outcomes....Pages 73-84
Results of Cord Blood Transplantation in Children with Nonmalignant Hematologic Conditions....Pages 85-106
Umbilical Cord Blood Transplantation for Inherited Metabolic Diseases....Pages 107-122
Myeloablative Single-Unit Cord Blood Transplantation in Adults....Pages 123-132
Quantitative and Qualitative Immune Reconstitution Following Umbilical Cord Blood Transplantation....Pages 133-152
Thymic Regeneration after Umbilical Cord Blood Transplantation: Mechanisms, Measurements and Implications on Anti-Viral Immunity....Pages 153-165
Cord Blood Transplantation in the East Mediterranean Region....Pages 167-175
Targeting Homing to Enhance Engraftment Following Umbilical Cord Blood Stem Cell Transplantation....Pages 177-191
Cord Blood Ex Vivo Expansion....Pages 193-202
Intra-bone Marrow Transplant (IBMT) of Cord Blood (CB) Cells: A Transplant Approach that Tries to Optimize Seeding Efficiency and Trafficking of Hematopoietic Stem Cells (HSCs)....Pages 203-210
Haplo-cord Transplantation: Overcoming the Limitations of Umbilical Cord Blood (UCB) Transplantation (UCBT)....Pages 211-220
Studies Comparing Haploidentical and Cord Blood Transplantation....Pages 221-234
Comparison of Umbilical Cord Blood to Adult Related and Unrelated Donors....Pages 235-255
Disease Specific Analysis of Cord Blood Transplantation for Adults and Clinical Results of Single and Double Umbilical Cord Blood Transplantation....Pages 257-268
Selection of the Optimal Cord Blood Unit....Pages 269-275
Back Matter....Pages 277-286