Ophthalmology

Recent Advances in Retinoblastoma Treatment

This book is a comprehensive resource on the current understanding of retinoblastoma. It addresses all the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by focal treatment, intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.

Table of contents :

Front Matter....Pages i-x

Molecular Biology of Retinoblastoma....Pages 1-13

Challenges of Genetic Susceptibility Testing for Retinoblastoma....Pages 15-26

Technique of Ophthalmic Artery Chemosurgery for Retinoblastoma....Pages 27-36

Vitreous Disease and the Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma....Pages 37-46

Electroretinogram Monitoring of Retinoblastoma Treatment....Pages 47-59

Pharmacokinetics of Chemotherapy Delivered by Ophthalmic Artery Chemosurgery....Pages 61-72

Drug Discovery and Repurposing for Retinoblastoma....Pages 73-84

Management of High-Risk Retinoblastoma....Pages 85-96

Treatment of Extraocular Retinoblastoma....Pages 97-103

Second Tumors in Retinoblastoma Survivors....Pages 105-112