Tuesday, January 17, 2017

Infections in Hematology

Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.
Table of contents : 
Front Matter....Pages i-viii
Front Matter....Pages 1-1
Infections in Patients with Acute Leukemia....Pages 3-23
Infections in Patients with Malignant Lymphomas....Pages 25-37
Consequences from Specific Treatment Modalities....Pages 39-47
Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation....Pages 49-61
Microbiological Background....Pages 63-87
Front Matter....Pages 89-89
The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations....Pages 91-111
Diagnostic Radiology in Hematological Patients with Febrile Neutropenia....Pages 113-135
Risk Stratification in Febrile Neutropenic Patients....Pages 137-152
Front Matter....Pages 153-153
Fever of Unknown Origin: Treatment According to Risk Assessment....Pages 155-163
Pulmonary Complications....Pages 165-185
Vascular Catheter-Related Infections....Pages 187-195
Gastrointestinal Complications....Pages 197-210
Central Nervous System Infections....Pages 211-226
Front Matter....Pages 227-227
Antibacterial Agents....Pages 229-258
Antifungal Agents....Pages 259-272
Front Matter....Pages 273-273
Antimicrobial Prophylaxis in Hematology....Pages 275-296
Infection Control and Hospital Epidemiology in Hematology Units....Pages 297-313
Myeloid Growth Factors....Pages 315-324
Back Matter....Pages 325-335