Biopharmaceutics and Pharmacokinetics
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development.
The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Table of contents :
Front Matter....Pages i-ix
Front Matter....Pages 1-1
Introduction to Pharmacodynamics....Pages 3-22
In Vitro and Animal PK/PD Models....Pages 23-44
Setting Clinical MIC Breakpoints from a PK/PD Point of View: It Is the Dose That Matters....Pages 45-61
Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling....Pages 63-79
Pharmacodynamic In Vitro Models to Determine the Effect of Antibiotics....Pages 81-112
Population Pharmacokinetic–Pharmacodynamic (PK/PD) Modeling of Anti-infective Agents and Its Applications to Individualized Therapy....Pages 113-134
Suppressing Resistance Development....Pages 135-151
Drug–Drug Combinations....Pages 153-198
Front Matter....Pages 199-199
Aminoglycosides....Pages 201-222
Continuous Infusion of Beta-lactam Antibiotics....Pages 223-255
Macrolides and Ketolides....Pages 257-278
Glycopeptides....Pages 279-322
Clinical Pharmacodynamics of Quinolones....Pages 323-349
Pharmacokinetics and Pharmacodynamics of Colistin....Pages 351-380
Daptomycin: Pharmacokinetic, Pharmacodynamic, and Dose Optimization....Pages 381-399
PK/PD of Oxazolidinones....Pages 401-443
Tigecycline....Pages 445-456
Back Matter....Pages 457-466
