Coagulation and Hemostasis
Hemostasis and thrombosis: basic principles and clinical practice
Hemostasis and Thrombosis, Sixth Edition
Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.
NEW to the Sixth Edition…
• A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.
• Full color throughout
• A companion website that offers full text online and an image bank.
• A new introductory section of chapters on basic sciences as related to the field
• Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
• Overview chapters preceding each section address broad topics of general importance.
Table of contents :
Content: Part I: Introduction to the field of hemostasis and thrombosis. Coagulation enzymology --
Cell biology, protein processing, and cell signaling --
Cellular and molecular immunology --
Biostatistics and epidemiology: the basic science of clinical research --
Part II: Basic hemostasis and thrombosis. Coagulation & fibrinolysis --
Overview of basic coagulation and fibrinolysis --
The blood coagulation factors and inhibitors: complementary DNAs, genes and expression --
Genetics of coagulation proteins --
Tissue factor and the initiation and regulation (TFPI) of coagulation --
Factors V and VIII --
Structure and function of von Willebrand factor --
Structure and function of vitamin K-dependent coagulant and anticoagulant proteins --
Factor XI --
The Factor XII-driven plasma contact system --
Fibrinogen structure and function --
Factor XIII --
Antithrombin and the serpin family --
Protein C and S and thrombomodulin system --
Plasminogen activation and regulation of fibrinolysis --
Inhibitors of fibrinolysis --
Platelet biology --
Overview of platelet structure and function --
Platelet production: cellular and molecular regulation --
Megakaryocyte structure and platelet biogenesis --
Thrombopoietin --
Major platelet glycoproteins: GPIb-IX-V --
Major platelet glycoproteins: GPIIb/IIIa --
Platelet glycoprotein polymorphisms and relationship to function and immunogenicity --
The basis for platelet adhesion --
Shear effects on platelets and the vessel wall in the pathogenesis of atherothrombosis --
Platelets and collagen --
Integrin [alpha]iib [beta]3 and platelet aggregation --
Molecular basis for platelet secretion --
Platelet signal transduction --
Platelet prostaglandin metabolism --
The role of platelets in blood coagulation --
Blood-borne microparticles --
Overview of vascular biology --
Development of the vasculature, angiogenesis, lymphangiogenesis --
Rheology and vessel wall stress --
Nitric oxide --
Blood vessel wall in health and disease --
Endothelial cell function --
Role of endothelium in hemostasis --
Coagulation-independent signaling of the extrinsic coagulation pathway --
Heparin and vascular proteoglycans --
Endothelial cell-blood cell interactions --
Leukocyte function and contribution to disease --
Laboratory markers of endothelial cell activation and dysfunction --
Part III: Disorders of coagulation, platelets, and vessel wall. Bleeding disorders coagulation & fibrinolysis --
Overview of inherited hemorrhagic disorders --
Differential diagnosis of the bleeding patient --
Clinical manifestations and therapy of inherited and acquired hemophilia --
von Willebrand Disease: diagnosis, classification, and treatment --
Rare inherited coagulation disorders other than hemophilia --
Afibrogenemias and dysfibrogenemias --
Familial multiple coagulation factor deficiencies --
Clinical disorders of fibrinolysis --
Acquired disorders of coagulation: the immune coagulopathies --
Laboratory markers of coagulation and fibrinolysis --
Acquired & inherited platelet disorders --
Overview of acquired and inherited clinical platelet disorders --
Differential diagnosis of thrombocytopenia --
Immune thrombocytopenic purpura and posttransfusion purpura --
Drug-induced thrombocytopenia --
Inherited thrombocytopenias --
Acquired nonimmune thrombocytopenia --
Hereditary disorders of platelet function --
Acquired disorders of platelet function --
Laboratory markers of platelet activation --
Primary disorders of blood vessels --
Overview of primary disorders of blood vessels --
Disorders of connective tissue and extracellulara matrix --
Hereditary hemorrhagic telangiectasia --
Arteriovenous malformations and hemangiomas and cerebral cavernous malformations --
Aneurysms (large and small arteries) --
Intracranial hemorrhage --
Retinopathy --
Therapy of bleeding disorders --
Overview to therapy of bleeding disorders --
Management of acute hemorrhage --
Therapy with antifibrinolytic agents --
Transfusion medicine --
New approaches for the therapy of bleeding disorders, including gene therapy. Part IV: Thrombotic disorders. venous thrombotic disorders. Thrombophilia genetics --
Epidemiology and risk factors of venous thromboembolism --
Clinical manifestations and diagnosis of venous thromboembolism --
Venous thrombosis in unusual sites --
Sequelae of venous thromboembolic disease: postthrombotic syndrome and chronic thromboembolic pulmonary hypertension --
Prevention of venous thromboembolic disease --
Treatment of venous thromboembolic disease --
Arterial thrombotic disorders --
Overview of arterial thrombotic disorders --
Pathophysiology of atherosclerosis --
Acute coronary syndromes: manifestations and management --
Pathophysiology of thromboembolic stroke --
Prevention of thromboembolic stroke in patients with atrial fibrillation, valvular heart disease, cardiomyopathy --
Acute stroke: general management, anticoagulant, and thrombolytic therapy --
Medical and surgical treatment of peripheral arterial disease --
Unusual sites of arterial occlusion --
Pathogenesis and treatment of biomaterial-associated thrombosis --
Complex thrombotic disorders --
Overview of microvascular and complex thrombotic disorders --
Consumptive thrombohemorrhagic disorders --
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome-microangiopathies --
Vasculitides --
Antiphospholipid antibodies and the antiphospholipid syndrome --
Thrombohemorrhagic complications of myeloproliferative disorders --
Thrombotic and hemorrhagic complications associted with stem cell transplantation --
Therapeutic agents --
Overview of therapeutic agents used in thrombotic disorders --
Pharmacology and mode of action of heparin and glycosaminoglycans --
Vitamin K antagonists: biochemistry, pharmacology and management --
Hemorrhagic complications of anticoagulation --
Heparin-induced thrombocytopenia --
Coumarin-induced skin necrosis and venous limb gangrene --
New antithrombotic drugs --
Antiplatelet therapy --
Thrombolytic therapy --
Anticoagulant and procoagulant proteins in the animal kingdom --
Mechanical devices and embolectomy --
Part V: Hemostatic and thrombotic disorders associated with systemic conditions. overview of special clinical groups --
VTE during pregnancy and with hormonal contraceptives --
Gestational vascular complications --
Maternal hemostatic disorders and obstetric hemorrhage --
Developmental hemostasis --
Bleeding in neonates and children --
Venous and arterial thromboembolism in children --
Thrombotic complications of sickle cell disease --
Thrombohemorrhagic complications of sepsis --
Hemorrhagic fevers: epidemiology, pathophysiology, and clinical features --
Cancer-related thrombosis --
Hemostatic abnormalities in liver disease --
Hemostatic abnormalities in renal disease --
Multitrauma derangements in hemostasis and thrombosis --
Blood management in the cardiovascular surgery patient --
Thrombo-hemorrhagic events in the elderly.
