Hematology
Nonmalignant Hematology: Expert Clinical Review: Questions and Answers
This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers will find that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.
Table of contents :
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Evaluation of Anemia in Children and Adults....Pages 3-12
Iron Homeostasis and the Pathophysiology and Management of Iron Deficiency....Pages 13-22
Porphyrias: Diagnosis and Management....Pages 23-28
Disorders of Hemoglobin Synthesis: Pathophysiology and Diagnostic Evaluation....Pages 29-37
Management of Thalassemias....Pages 39-51
Allogeneic Hematopoietic Cell Transplant in β-Thalassemia Major....Pages 53-61
Sickle Cell Disease: Prevention of Complications....Pages 63-73
Sickle Cell Disease: Management of Complications....Pages 75-87
Allogeneic Hematopoietic Cell Transplant in Sickle Cell Disease....Pages 89-96
Anemia of Inflammation....Pages 97-102
Iron Overload: Diagnosis, Complications, and Management....Pages 103-112
Megaloblastic and Nutritional Anemias....Pages 113-123
Sideroblastic Anemias: Diagnosis and Management....Pages 125-135
Primary Autoimmune Warm Antibody Hemolytic Anemias....Pages 137-152
Intrinsic Hemolytic Anemias: Pathophysiology, Diagnosis, and Management....Pages 153-167
Front Matter....Pages 169-169
Platelet Disorders: Diagnostic Tests and Their Interpretations....Pages 171-183
Inherited Platelet Disorders: Diagnosis and Management....Pages 185-197
Acquired Platelet Disorders: Diagnosis and Management....Pages 199-207
Immune-Mediated Thrombocytopenia....Pages 209-220
Coagulation Cascade and Fibrinolysis Pathway: Assessment in the Laboratory....Pages 221-233
Front Matter....Pages 169-169
Abnormalities in the Fibrinolysis Pathway and Clinical Implications....Pages 235-242
Congenital Disorders of Fibrinogen: Clinical Presentations, Diagnosis and Management....Pages 243-254
Hemophilia A and B: Diagnosis and Management....Pages 255-262
Coagulation Factor Inhibitors: Diagnosis and Management....Pages 263-272
Rare Coagulation Factor Deficiencies: Diagnosis and Management....Pages 273-283
von Willebrand Disease: Differential Diagnosis and Diagnostic Approach to Specific Subtypes....Pages 285-293
von Willebrand Disease: Prevention of Complications and Management of the Disease....Pages 295-311
Antifibrinolytics: Indications and Precautions....Pages 313-319
Gene Therapy for Bleeding Disorders....Pages 321-336
Front Matter....Pages 337-337
Disseminated Intravascular Coagulation....Pages 339-347
Coagulopathy in Critically Ill Subjects....Pages 349-359
Trauma-Associated Coagulopathy....Pages 361-367
Coagulation-Related Issues in Malignant Hematology: Diagnosis and Management....Pages 369-378
Unmet Clinical Needs of Antithrombotic Treatment in BCR/ABL-Negative Myeloproliferative Neoplasms....Pages 379-393
Bleeding and Thrombosis in a Cancer Patient....Pages 395-402
Management of the Surgical Patient with Thrombotic and Bleeding Diathesis....Pages 403-413
Front Matter....Pages 415-415
Prevention and Treatment of Arterial Thromboembolism....Pages 417-428
Prevention of Venous Thromboembolism....Pages 429-443
Diagnostic, Prognostic, and Therapeutic Challenges in Venous Thromboembolism....Pages 445-461
Complications of Venous Thromboembolic Disease....Pages 463-474
Front Matter....Pages 415-415
Hereditary Thrombophilias: Pathophysiology, Timing of Testing and Familial Testing....Pages 475-484
Antiphospholipid Antibodies and Syndrome: Complexities in Diagnosis and Management....Pages 485-494
Unidentifiable Thrombophilia....Pages 495-502
Anticoagulation Drugs: Indications, Therapeutic Monitoring, and Antidotes....Pages 503-517
Heparin-Induced Thrombocytopenia: Diagnosis and Management....Pages 519-529
Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome....Pages 531-547
Surgical Treatment of Thromboembolic Disease....Pages 549-560
Front Matter....Pages 561-561
Nonmalignant Leukocyte Disorders....Pages 563-573
Primary Immunodeficiency Disorders: Diagnosis and Management....Pages 575-584
Disorders of Phagocytic Function: Diagnosis and Treatment....Pages 585-594
Inherited Bone Marrow Failure Syndromes....Pages 595-609
Hemophagocytic Lymphohistiocytosis: Diagnosis and Management Challenges....Pages 611-617
Lysosomal Storage Disorders: Haematology Perspective....Pages 619-631
Cryoglobulins and Cryoglobulinemia....Pages 633-645
Front Matter....Pages 647-647
Reproductive Issues in Women with Bleeding and Thrombotic Disorders....Pages 649-659
Pregnancy in Subjects with Hemoglobinopathies: Precautions and Management....Pages 661-668
Neonatal Thrombosis and Coagulopathies....Pages 669-676
Bleeding and Thrombosis in the Elderly....Pages 677-684
Front Matter....Pages 685-685
Transfusion Support: Indications, Efficacy, and Complications....Pages 687-696
Human Blood Antigens and Antibodies: Diagnostic and Therapeutic Implications....Pages 697-705
Front Matter....Pages 685-685
Therapeutic Apheresis in Hematologic Disorders: When and Why?....Pages 707-718
