Laboratory Hemostasis: A Practical Guide for Pathologists



Coagulation testing is the basis for the diagnosis of bleeding and thrombotic disorders, as well as the mainstay of anticoagulant monitoring and management. This handbook provides practical information and guidance on topics relevant to directing a coagulation laboratory, filling a void in the literature. Since the first edition, all chapters have been updated and an entirely new chapter is included on pharmacogenomics and pharmacogenetics. The book will aid pathologists, clinical laboratory scientists and other physicians serving as laboratory directors to understand and carry out their responsibilities. It will also assist residents and fellows in learning the basics of coagulation testing and serve as a useful day-to-day reference for coagulation laboratory supervisors, technologists, and technicians. Finally, clinicians may find aspects of the book helpful in understanding the role of the coagulation laboratory in patient evaluation and monitoring.

Table of contents : 
Front Matter....Pages i-xii
Role and Responsibilities of the Laboratory Director....Pages 1-17
Collection of Coagulation Specimens....Pages 19-32
Instrumentation for the Coagulation Laboratory....Pages 33-43
Validation of Hemostasis Assays, Analyzers, and Reagents....Pages 45-67
Hemostasis Screening Assays....Pages 69-81
Testing for Inherited Bleeding Disorders....Pages 83-97
Testing for Acquired Platelet Disorders....Pages 99-110
Acquired Coagulation Disorders and TTP....Pages 111-116
Testing for Inherited and Acquired Thrombotic Disorders....Pages 117-134
Monitoring of Anticoagulant Therapy....Pages 135-171
Pharmacogenetic Testing for Anticoagulant and Antiplatelet Therapies....Pages 173-181
Coagulation Testing and Transfusion Medicine....Pages 183-199
Back Matter....Pages 201-205